Johnny Wang 8/1/26 Johnny Wang 8/1/26

Why Your Statin Stops Working: The Hidden Brake Inside Your Own Body — and the First Oral PCSK9 Pill

Double your statin dose and your cholesterol barely moves — because your own body fights back, cranking up a protein called PCSK9. Here's how that hidden "brake" works, and why the first oral PCSK9 pill matters.

Johnny Wang 7/15/26 Johnny Wang 7/15/26

Nearly 90% Protein Knockdown — and It Still Lost: The Real Deciding Factor Behind Ionis, Alnylam, and ATTR Cardiomyopathy

Johnny Wang 6/9/26 Johnny Wang 6/9/26

KRAS Cracked: The 40-Year Battle That Ended with a Standing Ovation at ASCO 2026

KRAS was called "undruggable" for 40 years. At ASCO 2026, daraxonrasib doubled survival in pancreatic cancer — and the room stood up for 42 seconds.

Johnny Wang 6/1/26 Johnny Wang 6/1/26

Why Oral Insulin Failed for 100 Years — But Oral GLP-1 Succeeded

Insulin has been injected since 1922, and scientists have chased an oral version ever since — yet after 100 years it's still a shot, while oral GLP-1 (Rybelsus) succeeded. This episode explains why the difference comes down to one word: delivery.